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Job Description

Scientist/Sr Scientist, Immunology/Cancer Immunotherapy/Pre-clinical

Responsibilities:

  • Independently design and conduct high-quality experiments and elaborate, interpret in vitro assays to quantify the functions of drug candidates
  • Execute experiments with scientific rigor in a fast-paced, matrixed research environment
  • Responsible for data analysis, thorough documentation of work, clear communication of results with the manager and in a group setting
  • Ability to establish new immunological assays to explore mechanisms of action and support the development of clinical candidates with desired pharmacologic properties
  • Support and analyze translational and animal models assessing the efficacy, PK, and safety of biologic immunotherapies in preclinical development
  • Work both independently and in close collaboration with other scientists in the preclinical group and across all research

Qualifications:

  • PhD in immunology or a related field, preferably with several years of a relevant postdoc or industry experience
  • Demonstrated research skills in cell biology, immunology, and preferably immuno-oncology
  • Technical expertise in multi-parameter flow cytometry, with proficiency in data analysis using software including FACS Diva, FlowJo, Prism, and Excel
  • Extensive hands-on experience in cell culture (primary human and mouse cells and human cell lines), blood and tissue sample processing
  • Broad hands-on experience in immunological techniques and immune-based assays including in vitro/ex vivo T, NK, Treg, DC cell functional assays (e.g., proliferation/expansion, activation, tumor target-cell killing, and cytokine responses, etc)

Benefits:

AskGene offers competitive salary and benefits. Job title and compensation will be commensurate with education and experience. Main benefits include 401K match, performance-based bonus, health insurance, and paid time off.

AskGene is committed to creating a diverse environment. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.

Research Scientist / Senior Scientist

Main Responsibilities

In this role, you will primarily be responsible for discovering lead molecules for IL-12 and other cytokine-based therapeutics.

Key responsibilities include:

  • Design experiments for cytokine drug discovery and lead screening.
  • Design protein molecules and clone them into expression vectors.
  • Transient expression of recombinant proteins and antibodies using mammalian cells.
  • Protein/Antibody biochemical characterization and interaction analysis using methods including SDS-PAGE, ForteBio Octet, ELISA, and/or FACS.
  • Work with mammalian cell-based protein expression and generate stable cell lines for research use.
  • Develop biochemical or cellular assays according to the projects.
  • Harvest and purify antibodies and proteins from transient expression when needed.

Qualifications:

  • PHD’s degree or postdoctoral experience on Immunology, Cell Biology, Molecular Biology, Biochemistry, or related fields; Strong working knowledge on immunology, molecular biology, and/or cellular biology.
  • Previous experience in drug discovery in pharma and/or biotech environment is preferred but not required.
  • Background or hands-on experience with NK cells, T cells, and/or macrophages is a plus.
  • Research experience and/or knowledge in the biology or structure of IL-12 or other cytokines is a plus.
  • Research experience in antibody discovery and/or engineering is a plus.
  • Knowledge or experience with protease is also a plus.
  • Expertise and hands-on experience in molecular biology including vector construction, PCR, and DNA preparations and/or cell culture is required.
  • Strong skills in problem-solving and ability to carry out independent research.
  • The scientist must keep excellent documentation and will prepare technical reports.
  • Good written and oral communication skills.
  • Must be a team player.

**For immediate consideration, please email your updated resume to Chunxiao.Yu@ask-gene.com

with ‘Research Scientist ‘ in the subject line.
Benefits

AskGene Pharma Inc. offers competitive salary and benefits. Main benefits include 401K match, performance-based bonus, medical insurance, and paid vacation per year.

Job Type: Full-time

Scientist / Senior Scientist, Antibody Discovery

Job Description

Company

AskGene Pharma Inc. is a growing start-up biotech company.  It aspires to become the global leader in the cytokine prodrug filed. It locates in the desirable Southern California coast, Camarillo, California, which is about 45 miles north of Los Angeles and about 55 miles south of Santa Barbara.

For further information, please visit company website: http://www.ask-gene.com/

Main Responsibilities

  • You will primarily be responsible for antibody discovery and protein/antibody engineering.

Further responsibilities include:

  • Lead the efforts in antibody discovery, humanization and/or optimization with the combination of in-house efforts and CROs
  • Work with CROs to carry out antibody discovery; apply methods including hybridoma technology, yeast library, and phage library.
  • Design and optimize bispecific antibody-cytokine fusion molecules in order to achieve intended biological functionalities and improved developability.
  • Work with teams to carry out molecule screening in order to identify lead molecules for further development.

Qualifications:

  • PHD’s degree preferably with postdoctoral experience in Immunology, Cell Biology, Molecular Biology, Biochemistry or related field.
  • Previous experience in antibody discovery is preferred; direct experience with hybridoma technology, yeast library and/or phage display is a plus.
  • Knowledge of antibody/protein engineering patent landscape is preferred.
  • Experience on PyMol, MOE, Rossetta, or other relative software is preferred.
  • Strong skills in problem-solving and ability to carry out independent research.
  • The scientist must keep excellent documentation and will prepare technical reports.
  • Good written and oral communication skills.
  • Must be a team player.

Benefits

AskGene Pharma Inc. offers competitive salary and benefits. Main benefits include 401K match, performance-based bonus, medical insurance, and three weeks of paid vacation per year.

For immediate consideration, please email your resume to Chunxiao.Yu@ask-gene.com             

with ‘Antibody Engineer ‘ in the subject line.